|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
White fat cells secrete adipokines that induce inflammation and obesity has been reported to be characterized by high serum levels of inflammatory cytokines such as IL-6 and TNF-α.
|
22513335 |
2012 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Weight loss in obese subjects was associated with opposite changes in the secretion and transcription of IL-8 and TNF-alpha in the adipose tissue, as well as in plasma.
|
12055326 |
2002 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We previously reported the up-regulation of TNF-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in adipose tissue of severely obese type 2 diabetic subjects.
|
20382683 |
2010 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of berberine on obesity and insulin resistance by examining the lipopolysaccharide (LPS)/toll-like receptor 4 (TLR4)/tumor necrosis factor (TNF)-α signaling pathway in livers of HFD-fed obese rats.
|
29365334 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We further assessed the contribution of the chronic inflammatory environment in obese adipose tissue to the dysregulated miRNA expression by tumor necrosis factor (TNF)-alpha treatment of adipocytes.
|
19188425 |
2009 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We found a relation between G174C polymorphism in IL-6 gene and G308A in TNF-alpha gene with the occurrence of obesity.
|
20156727 |
2009 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We examined the expression of candidate genes involved in adipocyte proliferation and/or differentiation [CCAAT/enhancer-binding protein (C/EBP) alpha, C/EBPdelta, GATA domain-binding protein 3 (GATA3), C/EBPbeta, peroxisome proliferator-activated receptor (PPAR) gamma2, signal transducer and activator of transcription 5A (STAT5A), Wnt-10b, tumor necrosis factor alpha, sterol regulatory element-binding protein 1c (SREBP1c), 11 beta-hydroxysteroid dehydrogenase, PPARG angiopoietin-related protein (PGAR), insulin-like growth factor 1, PPARgamma coactivator 1alpha, PPARgamma coactivator 1beta, and PPARdelta] in subcutaneous adipose tissue from 42 obese individuals with type 2 diabetes and 25 non-diabetic subjects matched for age and obesity.
|
17030965 |
2006 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We evaluated the association between ghrelin isoforms (acylated and desacyl ghrelin) and TNF-α in obesity and obesity-associated type 2 diabetes, as well as the potential role of ghrelin in the control of apoptosis and autophagy in human adipocytes.
|
22869322 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We determined FOXO1 expression and activity, insulin and NF-κB signaling, and pro-inflammatory cytokine production in tumor necrosis factor-α (TNF-α)- or dexamethasone (DEX)-induced IR model in vitro and in high fat diet-induced obese or diabetic db/db mice in vivo with quantitative RT-PCR and Western blotting.
|
22223069 |
2012 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We confirmed that the plasma sP‑selectin levels were increased in patients with obesity (particularly pericardial obesity) and hyperlipidemia, positively correlated with plasma tumor necrosis factor (TNF)‑α and strongly negatively correlated with adiponectin in all patients regardless of AMI status.
|
25384966 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude that the linkage of TNF-alpha to obesity might be due to a sequence variant undetected in TNF-alpha or due to a variant in some other closely linked gene.
|
7615786 |
1995 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We conclude hypoxia or obesity induces release of inflammatory TNFα and MCP-1 from mice primary adipocytes but the two environmental conditions do not synergize to worsen macrophage signal transduction or insulin responsiveness.
|
31677795 |
2020 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
We analysed the levels of cytokines (tumour necrosis factor [TNF] α and interleukins [ILs] 1β, 4, 6 and 10), chemokines (stromal cell derived factor 1α, monocyte chemoattract protein [MCP] 1, eotaxin and fractalkine) and growth factors (brain-derived neurotrophic factor, pro-fibrotic platelet-derived growth factor [PDGF-BB] and insulin-like growth factor 1) in serum of prepubertal children with obesity (61 girls/59 boys, 50% IR and 50% non-IR) and 32 controls.
|
30350467 |
2019 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analysed -308G/A polymorphism of TNF-α gene and studied its association with obesity and biochemical parameters.
|
21846948 |
2011 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Visceral white adipose tissue (WAT) has been closely associated with obesity-induced inflammation and adipose tissue macrophages (ATMs) are responsible for obesity-induced inflammation by releasing inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-6.
|
28985514 |
2017 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Using both parametric and nonparametric methods, we found no evidence of linkage of obesity to any of nine candidate genes/regions, including the Prader-Willi chromosomal region (PWS), the human homologue of the mouse agouti gene (ASP), and the genes for leptin (OB), the leptin receptor (OBR/DB), the beta3-adrenergic receptor (ADRB3), lipoprotein lipase (LPL), hepatic lipase (LIPC), glycogen synthase (GYS), and tumor necrosis factor alpha (TNFA).
|
9326333 |
1997 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Upregulated expression of resistin, vaspin, apelin and TNF-α plays a significant role in induction of insulin resistance linked with obesity and type 2 diabetes.
|
29229313 |
2018 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Type 2 diabetes: In a preclinical study in rats where obesity was alimentary induced, the administration of BE significantly reduced food intake, overweight, proinflammatory cytokines such as interleukin-1ß (IL-1ß), and tumor necrosis factor-α (TNF-α) and ameliorated the parameters of glucose and lipid metabolism.
|
31301539 |
2019 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
CTD_human |
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.
|
9502777 |
1998 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Treatment Failure of TNF-α Inhibitors in Obese Patients With Inflammatory Bowel Disease-A Cohort Study.
|
29788214 |
2018 |
|
Obesity
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Transcript levels of TNFα were significantly higher by 1.4-fold and 2.1-fold in blood cells of overweight/obese and breast cancer patients, respectively, compared with lean control subjects.
|
24961464 |
2014 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis.
|
19808894 |
2010 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
Together, being obese and TNF-308GA+AA increased DLBCL risk almost 2-fold relative to those of normal weight and TNF-308GG (OR = 1.93; 95% CI, 1.27-2.94), with a RERI of 0.41 (95% CI, -0.05-0.84; Pinteraction = 0.13).
|
25962811 |
2015 |
|
Obesity
|
0.400 |
Biomarker
|
disease |
BEFREE |
To understand the mechanism(s) behind this downregulation, we performed an in silico analysis of the three most relevant GHR gene promoters, which revealed putative response elements (REs) for a number of obesity adipose-associated factors, including tumor necrosis factor-alpha (TNFα), hypoxia-inducible factor-1-alpha (HIF-1α) and glucocorticoids.
|
21386799 |
2011 |
|
Obesity
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether the G-308A polymorphism of the TNF-α gene may influence obesity, insulin resistance, fasting plasma lipids, serum leptin levels, and the incidence of metabolic syndrome.
|
21147642 |
2010 |